Invasive risk stratification and implantable loop recorders in brugada syndrome: a single centre experience

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Risk stratification in Brugada syndrome (BrS) is challenging. Cardiogenic syncope, family history sudden cardiac death and ECG markers are useful variables determining patient risk. Invasive risk sometimes needed those with an intermediate phenotype. Implantable loop recorders (ILR) may be considered patients no inducible ventricular arrythmias during programmed stimulation (PVS). Objective The aim this study was to retrospectively evaluate the outcome BrS referred for PVS ILR implantation. Methodology Demographic, clinical follow-up data seen clinic were analysed from hospital databases. A p vale <0.05 significant. Results 129 have been diagnosed since launching inherited arrhythmia service (53.5% males). 15 (high patients) had ICD (n=13, 10.1%) or PM (n=2, 1.6%) implanted because a arrest, arrhythmias, high grade AV Block cardiogenic syncope. 26 (20.2%) placed category, (65.4% Patients offered electrophysiology (EPS/PVS) depending on indication (Figure 1). Most male (65.4%), mean age 41.8±17.7 years at time stratification. 6 likely definite pathogenic mutation (n=5 19.2% SCN5A, n=1 3.8% MYBPC3). This group median Shanghai score 4.0±0.9. Gender (p=0.429), (p=0.246), genotype (p=0.273) shanghai (p=0.746) did not differ between strategies. (n=12, 9.3%) EPS/PVS offset. Ventricular arrhythmias induced 1 (8.3%), then implanted. rest day. EPS (n=14, 10.9%) initially insufficient grounds proceed EP study. (n=25, 19.4%) followed up 39 ± 21 months. monitoring identified actionable events 3 (12.0%) patients. One (4.0%) pacemaker sick sinus syndrome. Two (8.0%) recorded non-sustained arrhythmias. Both subjected EPS/PVS, one ICD. None who any significant follow up. Conclusion implantation has role stratifying do fulfil criteria referral. also keen invasive assessment EPS.